Abstract

Supercritical CO2 decellularized porcine tissues and organs can be used as biomaterial medical devices for human tissue engineering and regenerative medicine. Products derived from porcine skin, bone, cornea, artery, nerve, tendon, brain, pancreas, kidney, heart and liver have been extensively studied in our lab. Some of them have received regulatory approval from the FDA of the US, Taiwan, Singapore, Philippines, Vietnam, Thailand and India. Those biomaterials are biocompatible and can be implanted into humans for therapeutic purposes. A combination of those biomaterials with semiconductor chips can be implanted into specific target tissue for the detection of physiological conditions, as well as transmitting signals for disease treatment. We printed semiconductor chips on the acellular dermis(ADM), acellular porcine cornea(APC) and acellular dura membrane and tested the safety and efficacy for sensing biological signals like body temperature, blood sugar, and electric signals. Future applications for the diagnosis and treatment of certain disease conditions require further studies from people with knowledge from multidiscipline areas.